Hsiao P H, Chiu Y N, Tsai W Y, Su S C, Lee J S, Soong W T
Department of Pediatrics, National Taiwan University Hospital, Taipei.
J Formos Med Assoc. 1999 Jul;98(7):512-5.
Mental retardation is a major sequela of delayed treatment of congenital hypothyroidism. In this study, we investigated the intellectual outcomes of patients with congenital hypothyroidism diagnosed before a nationwide screening project started. Eighty-two patients had intelligence tests done while in the euthyroid state. Their mean intelligence quotient (IQ) was 78 +/- 21 (+/- SD) (n = 79). The mean verbal IQ was significantly higher than the mean full-scale IQ. The mean IQs of both ectopic thyroid (84 +/- 21, n = 28) and dyshormonogenic patients (85 +/- 14, n = 18) were significantly higher than that of patients with athyrosis (64 +/- 18, n = 19) (p < 0.05). Patients who were treated before 3 months of age had significantly higher mean IQs (90 +/- 16, n = 16) than those treated after 3 months (75 +/- 21, n = 63) (p < 0.01). Our results confirm that both patients with ectopic thyroids and those with dyshormonogenesis have better intellectual outcomes than athyrotic patients do, and that early treatment improves the intellectual outcome of patients with congenital hypothyroidism.
智力发育迟缓是先天性甲状腺功能减退症治疗延迟的主要后遗症。在本研究中，我们调查了在全国筛查项目启动之前被诊断为先天性甲状腺功能减退症患者的智力结局。82例患者在甲状腺功能正常状态下进行了智力测试。他们的平均智商（IQ）为78±21（±标准差）（n = 79）。平均言语智商显著高于平均全量表智商。异位甲状腺患者（84±21，n = 28）和激素合成障碍患者（85±14，n = 18）的平均智商均显著高于无甲状腺患者（64±18，n = 19）（p < 0.05）。3个月龄前接受治疗的患者平均智商（90±16，n = 16）显著高于3个月后接受治疗的患者（75±21，n = 63）（p < 0.01）。我们的结果证实，异位甲状腺患者和激素合成障碍患者的智力结局均优于无甲状腺患者，并且早期治疗可改善先天性甲状腺功能减退症患者的智力结局。
