Bertuglia S, Leger P, Colantuoni A, Coppini G, Bendayan P, Boccalon H
CNR Institute of Clinical Physiology, University of Pisa, Italy.
Technol Health Care. 1999;7(2-3):113-23.
Flowmotion was characterized in healthy controls and 61 Raynaud's phenomenon (RP) patients by spectral analysis of laser-Doppler perfusion monitoring (LDPM) tracings. Healthy subjects flowmotion patterns revealed a main frequency of 3 cycles per min (cpm) with another low frequency and heart rate synchronous components. A first group of RP patients presented a low frequency and heart rate frequency component but no significant difference in blood flow. The second group presented the predominating heart rate related frequency with low microvascular perfusion. The third group presented a flowmotion pattern with overlapping of heart rate and low frequency components. Patients with primary and secondary RP show specific changes in flowmotion, probably related to increased sympathetic nervous activity or vessel wall alterations causing disappearance of arteriolar tone and impairment of microvascular perfusion. The group of patients with overlapping frequency components presents an intermediate flowmotion pattern indicating a different grade of alterations in microvasculature.
通过对激光多普勒灌注监测（LDPM）描记图进行频谱分析，对健康对照者和61例雷诺现象（RP）患者的血流运动进行了特征描述。健康受试者的血流运动模式显示，主要频率为每分钟3个周期（cpm），还有另一个低频和与心率同步的成分。第一组RP患者呈现低频和心率频率成分，但血流无显著差异。第二组呈现以心率相关频率为主且微血管灌注较低的情况。第三组呈现心率和低频成分重叠的血流运动模式。原发性和继发性RP患者的血流运动表现出特定变化，可能与交感神经活动增加或血管壁改变导致小动脉张力消失和微血管灌注受损有关。频率成分重叠的患者组呈现出中间血流运动模式，表明微血管系统存在不同程度的改变。
