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在一种转化的大鼠细胞系中诱导平滑肌α肌动蛋白可在体外和体内抑制恶性特性。

The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.

作者信息

Okamoto-Inoue M, Kamada S, Kimura G, Taniguchi S

机构信息

Department of Dermatology, Kurume University School of Medicine, Japan.

出版信息

Cancer Lett. 1999 Aug 3;142(2):173-8. doi: 10.1016/s0304-3835(99)00150-0.

DOI:10.1016/s0304-3835(99)00150-0
PMID:10463773
Abstract

A normal rat fibroblast 3Y1 cell line expresses smooth muscle a actin and the expression of alpha actin is suppressed in the transformant (SR-3Y1-2) induced by a Raus sarcoma virus. Gene transfer with smooth muscle alpha actin into the SR-3Y1-2 cell line reduced growth and invasiveness in vitro, as well as tumor growth and experimental lung metastasis depending on the expression of the alpha actin. These results indicated that smooth muscle alpha actin is involved in the regulation of cell growth as well as cell motility and thus leads to the suppression of malignant phenotypes in transformed cells.

摘要

正常大鼠成纤维细胞3Y1细胞系表达平滑肌α肌动蛋白，而在劳氏肉瘤病毒诱导的转化细胞（SR - 3Y1 - 2）中α肌动蛋白的表达受到抑制。将平滑肌α肌动蛋白进行基因转移到SR - 3Y1 - 2细胞系中，可降低其体外生长和侵袭能力，以及肿瘤生长和实验性肺转移，这取决于α肌动蛋白的表达情况。这些结果表明，平滑肌α肌动蛋白参与细胞生长以及细胞运动的调节，从而导致转化细胞中恶性表型的抑制。

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The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.在一种转化的大鼠细胞系中诱导平滑肌α肌动蛋白可在体外和体内抑制恶性特性。
Cancer Lett. 1999 Aug 3;142(2):173-8. doi: 10.1016/s0304-3835(99)00150-0.
2
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