Jain A, Buddhiraja S, Khurana B, Singhal R, Nair D, Arora P, Gangwal P, Mishra S K, Uppal B, Gondal R, Kar P
Maulana Azad Medical College, New Delhi.
Trop Gastroenterol. 1999 Jan-Mar;20(1):36-9.
The present study was designed to evalutate the association of various risk factors such as smoking, alcohol, NSAIDs, inadequate dietary intake of fibres and consumption of spicy foods with chronic duodenal ulcer using a case-control design and to establish the association of Helicobacter pylori and duodenal ulcer using different diagnostic techniques in Indian subjects.
A total of 16 consecutive patients with endoscopically proven duodenal ulcer (DU) constituted the test group while 160 subjects with non-ulcer dyspepsia (NUD) were recruited as controls.
All subjects were interviewed based on a standard questionnaire and underwent an upper gastrointestinal endsocopy wherein multiple biopsies were taken for rapid urease test (RUT), histology and culture for detection of H. pylori. The serum samples of all the subjects were tested for the presence of antibodies against H. pylori using ELISA.
There were significantly greater number of smokers (80%) and alcoholics (58%) in the male population of DU group as compared to the controls (49% smokers & 15% alcoholics). Similar trend was seen in relation to history of chronic exposure to NSAIDs (29% in DU & 11% in NUD) and inadequate intake of fibre in diet (66% and 39% respectively). The overall prevalence of H. pylori was 82.5% in DU and 50.6% in NUD [p < 0.001].
In North Indian subjects, alcohol consumption, smoking, inadequate intake of fibre in diet and use of NSAIDs are the risk factors associated with doudenal ulcer disease. Further, infection with H. pylori is strongly associated with DU in the North Indian population.
本研究旨在采用病例对照设计评估吸烟、饮酒、非甾体抗炎药、膳食纤维摄入不足和食用辛辣食物等多种风险因素与慢性十二指肠溃疡的关联，并运用不同诊断技术确定幽门螺杆菌与十二指肠溃疡在印度受试者中的关联。
连续16例经内镜证实为十二指肠溃疡（DU）的患者组成试验组，同时招募160例非溃疡性消化不良（NUD）受试者作为对照组。
所有受试者均依据标准问卷接受访谈，并接受上消化道内镜检查，在此过程中采集多份活检组织用于快速尿素酶试验（RUT）、组织学检查和培养以检测幽门螺杆菌。所有受试者的血清样本均采用酶联免疫吸附测定（ELISA）检测幽门螺杆菌抗体。
与对照组（49%吸烟者和15%饮酒者）相比，DU组男性人群中的吸烟者（80%）和饮酒者（58%）数量明显更多。在慢性接触非甾体抗炎药病史（DU组为29%，NUD组为11%）和膳食纤维摄入不足方面（分别为66%和39%）也观察到类似趋势。DU组幽门螺杆菌总体患病率为82.5%，NUD组为50.6%[p<0.001]。
在北印度受试者中，饮酒、吸烟、膳食纤维摄入不足和使用非甾体抗炎药是与十二指肠溃疡疾病相关的风险因素。此外，幽门螺杆菌感染在北印度人群中与DU密切相关。
