用于定量分析阿特拉津、马拉硫磷和2,4-二氯苯氧乙酸尿液代谢物的同位素稀释高效液相色谱/串联质谱法。
Isotope dilution high-performance liquid chromatography/tandem mass spectrometry method for quantifying urinary metabolites of atrazine, malathion, and 2,4-dichlorophenoxyacetic acid.
作者信息
Beeson M D, Driskell W J, Barr D B
机构信息
National Center for Environmental Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia 30341, USA.
出版信息
Anal Chem. 1999 Aug 15;71(16):3526-30. doi: 10.1021/ac990130u.
We have developed an isotope dilution high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) method for quantifying the urinary metabolites of the pesticides atrazine, malathion, and 2,4-dichlorophenoxyacetic acid (2,4-D). Urine samples are extracted with an organic solvent, and the organic fraction is concentrated. The concentrate is then analyzed using HPLC/MS/MS. The limits of detection for the metabolites are less than 0.5 microgram/L (parts per billion) in 10 mL of urine, with a high degree of accuracy and precision.
我们开发了一种同位素稀释高效液相色谱/串联质谱法（HPLC/MS/MS），用于定量测定农药阿特拉津、马拉硫磷和2,4-二氯苯氧乙酸（2,4-D）的尿液代谢物。尿液样本用有机溶剂萃取，有机相浓缩。然后使用HPLC/MS/MS对浓缩物进行分析。这些代谢物在10 mL尿液中的检测限低于0.5微克/升（十亿分之一），具有高度的准确性和精密度。
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