Montecucco C, Gobbi G, Perlini S, Rossi S, Grandi A M, Caporali R, Finardi G
Servizio di Reumatologia, University of Pavia, Italy.
Clin Exp Rheumatol. 1999 Jul-Aug;17(4):407-12.
Using digitized M-mode and Doppler echocardiography, we evaluated left ventricular (LV) function in 54 patients (43 women and 11 men; mean age 50 years) suffering from active rheumatoid arthritis (RA) without obvious cardiovascular disease, and compared them with 54 age- and sex-matched normal subjects.
No differences were found in LV end-diastolic diameter, systolic function and parietal thickness between the patients and controls. However, a significant reduction in various indexes of LV diastolic function was found, including E/A (ratio of early to late filling waves of mitral inflow Doppler) and the peak lengthening rate of the LV diameter (an index of LV relaxation evaluated by M-mode echocardiography). The former was correlated with patient age and was independent of disease duration, while the latter was more markedly correlated with disease duration than with patient age.
The relationship between diastolic impairment and disease duration in active RA may open new perspectives in the study of RA-associated cardiovascular disease.
利用数字化M型和多普勒超声心动图，我们评估了54例无明显心血管疾病的活动性类风湿关节炎（RA）患者（43名女性和11名男性；平均年龄50岁）的左心室（LV）功能，并将他们与54名年龄和性别匹配的正常受试者进行比较。
患者与对照组之间在左心室舒张末期直径、收缩功能和室壁厚度方面未发现差异。然而，发现左心室舒张功能的各项指标显著降低，包括E/A（二尖瓣流入多普勒早期与晚期充盈波的比值）和左心室直径的峰值延长率（通过M型超声心动图评估的左心室松弛指标）。前者与患者年龄相关，且与病程无关，而后者与病程的相关性比与患者年龄的相关性更为显著。
活动性RA中舒张功能损害与病程之间的关系可能为RA相关心血管疾病的研究开辟新的视角。
