Templeton N S, Lasic D D
Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX 77030, USA.
Mol Biotechnol. 1999 Apr;11(2):175-80. doi: 10.1007/BF02915810.
The history of liposomes, progress in liposome gene delivery, and future directions are discussed. Specific characteristics of liposomes and DNA:liposome complexes have been identified that are essential for optimal delivery and gene expression. Of particular interest are the requirements for increased delivery and high levels of gene expression in vivo. At present, significant efforts are focused towards achieving specific delivery and gene expression in target organs and tissues.
本文讨论了脂质体的历史、脂质体基因递送的进展以及未来的发展方向。已确定了脂质体和DNA：脂质体复合物的特定特性，这些特性对于最佳递送和基因表达至关重要。特别令人感兴趣的是在体内提高递送效率和高水平基因表达的要求。目前，大量的努力都集中在实现靶器官和组织中的特异性递送和基因表达上。
