de Divitiis M, Rubba P
Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy.
Nutr Metab Cardiovasc Dis. 1999 Jun;9(3):133-42.
Despite the strong evidence that cholesterol-lowering treatment is effective in the primary and secondary prevention of coronary heart disease, there is a great discrepancy between the results relating to prognosis and the ability of this treatment to induce regression of coronary atheromatous plaques. Since hypercholesterolemia causes a dysfunction in vascular reactivity, improvement can also be ascribed to restoration of vascular relaxation capacity. This conclusion is supported by a wealth of clinical and experimental evidence.
尽管有强有力的证据表明降低胆固醇治疗在冠心病的一级和二级预防中有效，但在预后结果与这种治疗诱导冠状动脉粥样斑块消退的能力之间存在很大差异。由于高胆固醇血症会导致血管反应性功能障碍，改善也可归因于血管舒张能力的恢复。这一结论得到了大量临床和实验证据的支持。
