抗高血压药物的热力学电离常数。
Thermodynamic ionization constants of antihypertensive drugs.
作者信息
Agrawal Y K, Menon S K, Majumudar F, Jain V K
机构信息
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India.
出版信息
Boll Chim Farm. 1999 Jun;138(6):253-8.
PMID:10464974
Abstract
The thermodynamic ionization constants (pKa) of indapamide, clonidine and methyldopa have been determined at 25 degrees C and 35 degrees C by pH titration technique. The pKa varies linearly with mole fraction of dioxane. The thermodynamic parameters have been calculated.
摘要
通过pH滴定技术在25℃和35℃下测定了吲达帕胺、可乐定和甲基多巴的热力学电离常数（pKa）。pKa随二氧六环的摩尔分数呈线性变化。已计算出热力学参数。
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