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A phase II study of a three-drug combination (cisplatin, ifosfamide and vinorelbine) plus granulocyte-colony stimulating factor in advanced non small cell lung cancer.

作者信息

Tognoni A, Cadenotti L, Pensa F, Vaira F, Vigani A, Bancalari L, Cordani S, Maggiani R, Canessa P A, Pronzato P

机构信息

Dept. of Medical Oncology, Ospedale S. Andrea, La Spezia, Italy.

出版信息

J Chemother. 1999 Aug;11(4):306-9. doi: 10.1179/joc.1999.11.4.306.

DOI:10.1179/joc.1999.11.4.306
PMID:10465134
Abstract

Twenty-nine patients with advanced non-small-cell lung cancer (NSCLC) were treated with a combination of cisplatin 20 mg/m2 days 1-3, ifosfamide 1500 mg/m2 days 1-2 (plus mesna as uroprotector) and vinorelbine 25 mg/m2 days 1 and 5; filgrastim was given at the dose of 300 microg subcutaneously from day 8 to day 15. A response rate of 28% was observed. The activity of this combination in an outpatient setting, with acceptable toxicity, has been demonstrated.

摘要

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