Leonardos L, Butler L M, Hewett P J, Zalewski P D, Cowled P A
Department of Surgery, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.
Cancer Lett. 1999 Aug 23;143(1):29-35. doi: 10.1016/s0304-3835(99)00176-7.
Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/ 31 colonic carcinomas and adenomas when compared to normal mucosa (P < 0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (P < 0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.
活化的半胱天冬酶-3样蛋白酶通过切割细胞底物来促进凋亡性细胞死亡。在31例患者的结肠癌组织及其配对的正常结肠黏膜中检测了半胱天冬酶-3样活性，与正常黏膜相比，25/31的结肠癌和腺瘤组织中的该活性显著升高（P<0.0001）。女性受试者正常黏膜和肿瘤中的半胱天冬酶-3样活性比男性高得多（P<0.0001）。半胱天冬酶-3样活性与肿瘤位置、肿瘤分级、分期或患者年龄之间未发现相关性。结直肠癌中半胱天冬酶-3样活性的显著增加可能反映了自发凋亡细胞比例的增加。
