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Endothelin receptor antagonists reduce the pressor effects of angiotensin II into the periaqueductal gray area of rats.

作者信息

D'Amico M, Di Filippo C, Filippelli A, Rossi F

机构信息

Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, 2nd University of Naples, Italy.

出版信息

Life Sci. 1999;65(9):PL95-9. doi: 10.1016/s0024-3205(99)00327-6.

DOI:10.1016/s0024-3205(99)00327-6
PMID:10465357
Abstract

Injection of ANGII (0.01, 0.1 and 1 nmol/rat) into the periaqueductal gray (PAG) area significantly (P<0.01) increased, in a dose-dependent manner, the mean arterial blood pressure (MAP). The increases in blood pressure induced by ANGII (1 nmol; 37 +/- 4 mmHg, n=5) were greatly reduced (>85%) by pre-administration of the ET(A) receptor antagonist FR139317 (5 nmol/rat) to the PAG area, but were unaffected by the ET(B) receptor antagonist BQ-788 (5 nmol/rat). SB209670, non-selective ET(A)/ET(B) receptor antagonist, also reduced the effect induced by ANGII. These results suggest that endogenous endothelin-1, via an action on ET(A) receptors, may contribute to the pressor effects of ANGII within the PAG area of rats.

摘要

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