Corral C, Lissavetzky J, Manzanares I, Darias V, Expósito-Orta M A, Martïn Conde J A, Sánchez-Mateo C C
Instituto de Química Médica (CSIC), Madrid, Spain.
Bioorg Med Chem. 1999 Jul;7(7):1349-59. doi: 10.1016/s0968-0896(99)00070-x.
A series of eight thienyloxymethylmorpholines, thiophene analogues of viloxazine, have been synthesized by three different routes. The preliminary pharmacological evaluation of this series shows antidepressant properties on the mice models used with a light sedative action. The structure-activity relationship is established in a first approximation.
通过三种不同路线合成了一系列8种噻吩氧基甲基吗啉，即维洛沙嗪的噻吩类似物。该系列的初步药理学评估表明，在所使用的小鼠模型上具有抗抑郁特性，并伴有轻度镇静作用。初步建立了构效关系。
