Sastry P S
Royal Marsden Hospital, Sutton, Surrey, UK.
Med Hypotheses. 1999 Apr;52(4):353-4. doi: 10.1054/mehy.1997.0659.
The pathology of cutaneous T-cell lymphomas is predominantly in the skin. Allogeneic bone-marrow transplantation results in graft-versus-host disease involving the skin in many cases. It has been suggested that it would be interesting to see the effect of allotransplantation, even though no series has been reported so far. Adoptive immunotherapy with donor lymphocyte infusions has been increasingly used to treat post-transplant relapse and even prevention. The present hypothesis suggests that infusion of human leucocyte antigen (HLA)-matched donor lymphocyte infusions would result in a graft-versus-leukemia/lymphoma (GVL) effect in these disorders. Therefore, clinical trials are suggested.
皮肤T细胞淋巴瘤的病理学主要表现在皮肤。在许多情况下，异基因骨髓移植会导致涉及皮肤的移植物抗宿主病。有人提出，尽管目前尚无相关系列报道，但观察同种异体移植的效果可能会很有意思。供体淋巴细胞输注的过继性免疫疗法已越来越多地用于治疗移植后复发甚至预防。目前的假说认为，输注人类白细胞抗原（HLA）匹配的供体淋巴细胞会在这些疾病中产生移植物抗白血病/淋巴瘤（GVL）效应。因此，建议开展临床试验。
