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(-)-Pindolol increases dialysate concentrations of dopamine and noradrenaline, but not serotonin, in the frontal cortex of freely-moving rats.

作者信息

Millan M J, Gobert A

机构信息

Institut de Recherches Servier, Psychopharmacology Department, Paris, France.

出版信息

Neuropharmacology. 1999 Jun;38(6):909-12. doi: 10.1016/s0028-3908(99)00012-x.

DOI:10.1016/s0028-3908(99)00012-x
PMID:10465694
Abstract

(-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels were not significantly modified. In contrast, (-)-propranolol (2.5) did not modify FCX dialysate levels of DA, NA (or 5-HT) alone and abolished the facilitatory influence of (-)-pindolol (10.0) upon levels of DA, though not NA. In contrast to (-)-propranolol, (-)-pindolol exerts, a facilitatory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission.

摘要

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