Sarikaya I, Bektas A, Ibis E, Yasa M H, Bastemir M, Ormeci N, Aras G
Department of Nuclear Medicine, Ankara University Hospital, Turkey.
Clin Nucl Med. 1999 Apr;24(4):243-7. doi: 10.1097/00003072-199904000-00005.
Various radionuclide methods have been studied for the evaluation of the disease activity and extent of ulcerative colitis and other protein-losing enteropathies. Recently, Tc-99m dextran and Tc-99m human immunoglobulin (HIG) have been used to detect inflammation and protein loss into the intestine, but only a few studies have been reported with these agents.
In this study, Tc-99m dextran and Tc-99m HIG were used to evaluate disease activity and extent in patients with ulcerative colitis. These agents were used in 12 patients with active disease and in five patients in remission, and five healthy control participants also were included.
Large bowel activity was detected in 11 of the 12 patients with active ulcerative colitis using Tc-99m dextran and in 10 patients using Tc-99m HIG. Fifty-eight bowel segments were found to be active with endoscopy, 39 with Tc-99m dextran, and 31 with Tc-99m HIG. No intestinal activity was detected in the control participants. Grade 1 activity localization in the large bowel was detected in three patients with ulcerative colitis in remission using Tc-99m dextran and in one patient using Tc-99m HIG.
Tc-99m dextran is more sensitive for detecting disease activity and extent than is Tc-99m HIG.
已对多种放射性核素方法进行研究，以评估溃疡性结肠炎及其他蛋白丢失性肠病的疾病活动度和范围。近来，锝-99m标记的葡聚糖和锝-99m标记的人免疫球蛋白（HIG）已用于检测肠道炎症和蛋白丢失，但关于这些药物的研究报道较少。
在本研究中，锝-99m标记的葡聚糖和锝-99m标记的HIG用于评估溃疡性结肠炎患者的疾病活动度和范围。这些药物应用于12例活动期患者和5例缓解期患者，还纳入了5名健康对照者。
12例活动期溃疡性结肠炎患者中，11例使用锝-99m标记的葡聚糖检测到大肠有放射性，10例使用锝-99m标记的HIG检测到大肠有放射性。内镜检查发现58个肠段有活动，锝-99m标记的葡聚糖检测到39个，锝-99m标记的HIG检测到31个。对照者未检测到肠道放射性。3例缓解期溃疡性结肠炎患者使用锝-99m标记的葡聚糖检测到大肠有1级放射性，1例使用锝-99m标记的HIG检测到大肠有1级放射性。
锝-99m标记的葡聚糖在检测疾病活动度和范围方面比锝-99m标记的HIG更敏感。
