Min S K, An S K, Jon D I, Lee J D
Department of Psychiatry, College of Medicine, Yonsei University, Seoul, South Korea.
Psychiatry Res. 1999 Jun 30;90(3):159-68. doi: 10.1016/s0925-4927(99)00014-1.
In 17 antipsychotic-naive schizophrenic patients, the scores of positive and negative symptoms of schizophrenia were correlated with relative regional cerebral perfusion measured by 99m-Tc-ECD (ethyl cysteinate dimer) single photon emission computed tomography (SPECT). Scans were performed in subjects at rest. The negative symptom dimension was significantly correlated with a decreased level of perfusion in the left thalamic region. Other non-significant trends were also observed; the positive symptom dimension was related to decreased perfusion in the left temporal region and to increased perfusion in the right frontal region, while the negative symptom dimension was related to increased perfusion in the left frontal region. These findings suggest that the positive and negative symptoms of schizophrenia are related to dysfunctions in different regions of the brain and different lateralized patterns of dysfunction.
在17例未使用过抗精神病药物的精神分裂症患者中，精神分裂症的阳性和阴性症状评分与通过99m-Tc-ECD（半胱氨酸乙酯二聚体）单光子发射计算机断层扫描（SPECT）测量的相对局部脑灌注相关。扫描在受试者静息状态下进行。阴性症状维度与左丘脑区域灌注水平降低显著相关。还观察到其他无显著意义的趋势；阳性症状维度与左颞叶区域灌注降低及右额叶区域灌注增加有关，而阴性症状维度与左额叶区域灌注增加有关。这些发现表明，精神分裂症的阳性和阴性症状与大脑不同区域的功能障碍以及不同的功能障碍侧化模式有关。
