Pantel J, Schröder J, Jauss M, Essig M, Minakaran R, Schönknecht P, Schneider G, Schad L R, Knopp M V
Department of Psychiatry, Section of Geriatric Psychiatry, University of Heidelberg, Germany.
Psychiatry Res. 1999 Jun 30;90(3):181-92. doi: 10.1016/s0925-4927(99)00018-9.
It has been suggested that regional corpus callosum atrophy in Alzheimer's disease (AD) may serve as an in vivo index of neuronal loss in the neocortex. In this study total and regional size of the corpus callosum was evaluated with respect to the volumes of the frontal, temporal, and parietal lobes in 38 patients with AD (NINCDS-ADRDA criteria) using quantitative magnetic resonance imaging. Twenty healthy subjects matched for age and gender served as a control group. All quantitative measurements were performed by manual tracing using personal computer-based software. Both total size and the five measured regional subsections were significantly smaller in AD when compared to the control subjects. The severity of dementia was significantly correlated with the size of the middle sections of the corpus callosum (rostral body and midbody). Within the AD group, the rostral body of the corpus callosum was significantly correlated with the frontal lobe volumes, the midbody was correlated with the temporal lobe volumes, and size of the splenium was correlated with the parietal lobe volumes. We conclude that callosal atrophy in AD reflects the severity and pattern of cortical neuronal damage. Correlations between regional callosal atrophy and severity of dementia indicate that interhemispheric cortico-cortical disconnection may contribute to the dementia syndrome.
有人提出，阿尔茨海默病（AD）中胼胝体区域萎缩可能作为新皮质神经元丢失的一种活体指标。在本研究中，使用定量磁共振成像，针对38例符合NINCDS - ADRDA标准的AD患者的额叶、颞叶和顶叶体积，评估了胼胝体的总体积和区域体积。20名年龄和性别匹配的健康受试者作为对照组。所有定量测量均通过基于个人计算机的软件手动追踪进行。与对照组相比，AD患者的总体积和五个测量的区域亚部分均显著更小。痴呆严重程度与胼胝体中间部分（胼胝体嘴部和体部）的大小显著相关。在AD组内，胼胝体嘴部与额叶体积显著相关，体部与颞叶体积相关，压部大小与顶叶体积相关。我们得出结论，AD中的胼胝体萎缩反映了皮质神经元损伤的严重程度和模式。区域胼胝体萎缩与痴呆严重程度之间的相关性表明，半球间皮质 - 皮质连接中断可能导致痴呆综合征。
