通过屏气和功能磁共振成像评估脑氧化代谢
Assessment of cerebral oxidative metabolism with breath holding and fMRI.
作者信息
Kastrup A, Krüger G, Glover G H, Moseley M E
机构信息
Department of Radiology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Magn Reson Med. 1999 Sep;42(3):608-11. doi: 10.1002/(sici)1522-2594(199909)42:3<608::aid-mrm26>3.0.co;2-i.
Carbon dioxide inhalation can be used to map changes in cerebral metabolic rate of oxygen (CMRO(2)) during neuronal activation with functional MRI (fMRI). A hypercapnic stress also can be achieved with a simple breath-holding test. Using this test as means of manipulating cerebral blood flow (CBF) independent of CMRO(2), we assessed changes in CMRO(2) during visual stimulation. With this task, CBF increased by 61 +/- 7%, whereas CMRO(2) changed by 2.43 +/- 4.97%. These results are in good agreement with previous positron emission tomographic (PET) data, indicating that changes in oxidative metabolism during focal neuronal activity can potentially be determined with the breath-holding test. This test could easily be performed during a routine MRI examination. Magn Reson Med 42:608-611, 1999.
吸入二氧化碳可用于在功能磁共振成像（fMRI）的神经元激活过程中描绘脑氧代谢率（CMRO₂）的变化。通过简单的屏气试验也可实现高碳酸血症应激。利用该试验作为独立于CMRO₂来操纵脑血流量（CBF）的手段，我们评估了视觉刺激期间CMRO₂的变化。在此任务中，CBF增加了61±7%，而CMRO₂变化了2.43±4.97%。这些结果与先前的正电子发射断层扫描（PET）数据高度一致，表明局灶性神经元活动期间的氧化代谢变化可能通过屏气试验来确定。该试验可在常规MRI检查期间轻松进行。《磁共振医学》42:608 - 611, 1999年。
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