Patriarca F, Geromin A, Fanin R, Damiani D, Sperotto A, Baccarani M
Division of Haematology and Department of Bone Marrow Transplantation, Udine University Hospital, Udine, Italy.
Bone Marrow Transplant. 1999 Aug;24(4):433-5. doi: 10.1038/sj.bmt.1701925.
AL amyloidosis was diagnosed in a 56-year-old woman with spontaneous purpura, macroglossia and hepatomegaly, a serum IgGk monoclonal gammopathy and a 25% plasma cell bone marrow infiltration. She was started on high-dose treatment consisting of four monthly cycles of VID chemotherapy, then underwent a stem cell collection after priming with cyclophosphamide + G-CSF. Myeloablative therapy was with melphalan and busulfan. Hematologic recovery was fast and uncomplicated. At follow-up 22 months from ASCT, the patient shows a complete remission of the clonal plasma cell disorder, normalization of liver size and alkaline phosphatase level and a significant improvement in the signs of vascular and soft tissue amyloid infiltration.
一名56岁女性被诊断为AL淀粉样变性，伴有自发性紫癜、巨舌和肝肿大，血清IgGk单克隆丙种球蛋白病以及25%的浆细胞骨髓浸润。她开始接受高剂量治疗，包括四个月周期的VID化疗，然后在环磷酰胺+粒细胞集落刺激因子预处理后进行干细胞采集。清髓性治疗采用美法仑和白消安。血液学恢复迅速且无并发症。自自体造血干细胞移植（ASCT）后22个月的随访显示，患者的克隆性浆细胞疾病完全缓解，肝脏大小和碱性磷酸酶水平恢复正常，血管和软组织淀粉样浸润体征有显著改善。
