Hampl R, Morfin R, Starka L
Institute of Endocrinology, 116 94 Praha, Czech Republic.
Endocr Regul. 1997 Dec;31(4):211-218.
In the late fifties and early sixties our group has found that 3beta,7alpha-dihydroxy-5-androsten-17-one (7alpha-hydroxy-dehydroepiandrosterone) is a natural constituent of human body fluids. Later, the enzyme activity responsible for its formation has been demonstrated in many animal and human tissues including the foetal ones. The physiological role of this and related steroids has not been understood well for decades. As late as in 1994 Morfin and his group have shown that 7alpha-hydroxy-dehydroepiandrosterone may be a locally active metabolite, responsible for recently discovered immunostimulatory or immunomodulatory effects of dehydroepiandrosterone.
在五十年代末和六十年代初，我们团队发现3β,7α - 二羟基 - 5 - 雄甾烯 - 17 - 酮（7α - 羟基 - 脱氢表雄酮）是人体体液的一种天然成分。后来，在包括胎儿组织在内的许多动物和人体组织中都证实了负责其形成的酶活性。几十年来，这种及相关类固醇的生理作用一直未被很好地理解。直到1994年，莫尔芬及其团队才表明，7α - 羟基 - 脱氢表雄酮可能是一种局部活性代谢物，它导致了最近发现的脱氢表雄酮的免疫刺激或免疫调节作用。
