无麸质饮食可降低乳糜泻患儿的尿肽水平。
Gluten-free diet decreases urinary peptide levels in children with celiac disease.
作者信息
Ek J, Stensrud M, Reichelt K L
机构信息
Department of Pediatrics, Buskerud Central Hospital, Drammen, Norway.
出版信息
J Pediatr Gastroenterol Nutr. 1999 Sep;29(3):282-5. doi: 10.1097/00005176-199909000-00008.
BACKGROUND
Increased urine secretion of peptides has been found in celiac disease, probably resulting from increased intestinal uptake of peptides caused by damage to the small gut mucosa.
METHODS
High-performance liquid chromatography of low-molecular-weight peptides in the urine was performed over 6 months, before and after a gluten-free diet was instituted in children who clinically improved while consuming the diet.
RESULTS
A significant decrease of peptide levels was observed in children consuming the gluten-free diet. Certain peptide peaks thought to be gluten related decreased the most after the patients began the diet.
CONCLUSIONS
Because the peptides decrease in patients consuming a gluten-free diet, it is reasonable to conclude that such peptides have a mostly dietary origin.
背景
乳糜泻患者尿液中肽类分泌增加，这可能是由于小肠黏膜受损导致肠道对肽类的摄取增加所致。
方法
对临床症状在食用无麸质饮食期间有所改善的儿童，在采用该饮食前后的6个月内，对其尿液中的低分子量肽进行高效液相色谱分析。
结果
食用无麸质饮食的儿童肽水平显著降低。某些被认为与麸质相关的肽峰在患者开始饮食后下降最为明显。
结论
由于食用无麸质饮食的患者体内肽类减少，因此可以合理推断此类肽类主要来源于饮食。
Zotero 插件