Rizvi M A, Shah S R, Raskob G E, George J N
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Curr Opin Hematol. 1999 Sep;6(5):349-53. doi: 10.1097/00062752-199909000-00013.
Many drugs can induce thrombocytopenia mediated by drug-dependent antiplatelet antibodies. Recent studies have documented specific epitopes for drug-dependent antibody binding on glycoprotein Ib-IX, glycoprotein IIb-IIIa, and platelet-endothelial cell adhesion molecule-1. Molecular identification of antibody binding sites may help to identify susceptible individuals. Management of patients with unexpected thrombocytopenia who are taking multiple drugs remains a difficult clinical problem. A recent systematic review of all published case reports of drug-induced thrombocytopenia ranks drugs according to the strength of clinical evidence for a causal relation to thrombocytopenia. This database is available online at http://moon.ouhsc.edu/jgeorge.
许多药物可通过药物依赖性抗血小板抗体介导诱发血小板减少症。最近的研究已记录了药物依赖性抗体在糖蛋白Ib-IX、糖蛋白IIb-IIIa和血小板内皮细胞黏附分子-1上结合的特定表位。抗体结合位点的分子鉴定可能有助于识别易感个体。对于服用多种药物却出现意外血小板减少症的患者，其治疗仍是一个棘手的临床问题。最近一项对所有已发表的药物性血小板减少症病例报告的系统评价，根据与血小板减少症因果关系的临床证据强度对药物进行了排名。该数据库可在http://moon.ouhsc.edu/jgeorge在线获取。
