Schmidt P T, Rasmussen T N, Holst J J
Department of Medical Physiology, the Panum Institute, University of Copenhagen, Copenhagen N, Denmark.
Acta Physiol Scand. 1999 Aug;166(4):335-40. doi: 10.1046/j.1365-201x.1999.00532.x.
The precise role of tachykinins in regulation of acid and pepsinogen secretion has not been established. Tachykininergic effects on acid and pepsinogen secretion could be mediated either directly in the proximal stomach or through other indirect mechanisms, i.e. gastrin secretion. We studied the effects of the two tachykinins, substance P and neurokinin A, and of capsaicin, on acid and pepsinogen output, in isolated porcine non-antral stomach preparation. The release of substance P and neurokinin A was studied during electrical stimulation of the vagal nerves, and during capsaicin infusion. Substance P infusion (10-8 M) increased acid secretion from 30 +/- 8 to 68 +/- 17 fmol min-1 (n=6, P < 0.05) and pepsinogen output from 46 +/- 12 to 160 +/- 47 units of pepsin min-1 (n=9, P < 0.05). Neurokinin A also stimulated both acid and pepsinogen secretion, while capsaicin had no effect on either parameter. Electrical stimulation of the vagal nerves increased the release of both peptides. We conclude that tachykinins may be involved in regulation of acid and pepsinogen secretion.
速激肽在胃酸和胃蛋白酶原分泌调节中的精确作用尚未明确。速激肽对胃酸和胃蛋白酶原分泌的作用可能直接在胃近端介导，也可能通过其他间接机制，即胃泌素分泌来介导。我们在离体猪非胃窦部胃制备物中研究了两种速激肽即P物质和神经激肽A以及辣椒素对胃酸和胃蛋白酶原产生量的影响。在迷走神经电刺激期间以及辣椒素输注期间研究了P物质和神经激肽A的释放情况。输注P物质（10-8 M）使胃酸分泌从30±8增加至68±17 fmol min-1（n = 6，P <0.05），胃蛋白酶原产生量从46±12增加至160±47胃蛋白酶单位min-1（n = 9，P <0.05）。神经激肽A也刺激胃酸和胃蛋白酶原分泌，而辣椒素对这两个参数均无影响。迷走神经电刺激增加了两种肽的释放。我们得出结论，速激肽可能参与胃酸和胃蛋白酶原分泌的调节。
