Francis R M
Musculoskeletal Unit, Freeman Hospital, Newcastle upon Tyne, UK.
Clin Endocrinol (Oxf). 1999 Apr;50(4):411-4. doi: 10.1046/j.1365-2265.1999.00730.x.
Although the pathogenesis of osteoporosis in men is multi-factorial, testosterone is known to play an important role in the maintenance of the male skeleton. This role, however, appears complicated as it may be mediated in part by aromatization to oestradiol. Testosterone replacement therapy improves bone density in men with hypogonadal osteoporosis, particularly if the epiphyses are still open. There is no well-established treatment for idiopathic osteoporosis in men, but testosterone supplementation may prove to be useful. Further studies are required to confirm the safety and efficacy of this treatment in eugonadal men with osteoporosis.
尽管男性骨质疏松症的发病机制是多因素的，但已知睾酮在维持男性骨骼方面起着重要作用。然而，这一作用似乎很复杂，因为它可能部分通过芳香化转化为雌二醇来介导。睾酮替代疗法可改善性腺功能减退性骨质疏松症男性的骨密度，尤其是在骨骺仍未闭合的情况下。目前尚无针对男性特发性骨质疏松症的确立疗法，但补充睾酮可能会被证明是有用的。需要进一步研究以证实这种疗法在性腺功能正常的骨质疏松症男性中的安全性和有效性。
