Yagihashi N, Koyama M, Yagihashi S
First Department of Pathology, Hirosaki University School of Medicine, Japan.
Pathol Int. 1999 Jun;49(6):563-5. doi: 10.1046/j.1440-1827.1999.00904.x.
We describe a case of a rare variant of a rectal carcinoid tumor that showed mucous gland differentiation accompanied by a lymph node metastasis with a histological appearance similar to that of the primary site. The tumor consisted of a typical argyrophilic carcinoid component and of goblet cell glands. The carcinoid component was positive for neuron-specific enolase, chromogranin A and synaptophysin. The goblet cells stained positively with periodic acid-Schiff (PAS) and alcian blue, and expressed carcinoembryonic antigen, but were negative for neuroendocrine markers. This case suggests that carcinoid tumor can differentiate towards mucus glands, which can also be found in the metastatic site.
我们描述了一例罕见的直肠类癌肿瘤变异型病例，该肿瘤显示出黏液腺分化，并伴有组织学表现与原发部位相似的淋巴结转移。肿瘤由典型的嗜银性类癌成分和杯状细胞腺组成。类癌成分对神经元特异性烯醇化酶、嗜铬粒蛋白A和突触素呈阳性反应。杯状细胞对过碘酸希夫（PAS）染色和阿尔辛蓝染色呈阳性，并表达癌胚抗原，但神经内分泌标志物呈阴性。该病例提示类癌肿瘤可向黏液腺分化，且在转移部位也可发现。
