Cambiaghi S, Barbareschi M
Centre for Inherited Skin Disorders, Institute of Dermatological Sciences, IRCCS Policlinico, University of Milan, Italy.
Pediatr Dermatol. 1999 Jul-Aug;16(4):301-4. doi: 10.1046/j.1525-1470.1999.00079.x.
Hereditary hypotrichosis simplex of the scalp is a genotrichosis characterized by a hair defect limited to the scalp in the absence of other ectodermal or systemic abnormalities. Only large pedigrees consistent with autosomal dominant transmission have been described to date. In this article the clinical and scanning electron microscopy findings of a nonfamilial case of congenital scalp hypotrichosis simplex are reported. In some patients the diagnosis of sporadic hypotrichosis simplex of the scalp should be considered after ruling out all other possible causes of congenital and hereditary hypotrichosis.
遗传性单纯性头皮毛发稀少症是一种基因性毛发疾病，其特征为毛发缺陷仅限于头皮，且无其他外胚层或全身性异常。迄今为止，仅报道过符合常染色体显性遗传的大型家系。本文报告了一例先天性单纯性头皮毛发稀少症非家族性病例的临床及扫描电子显微镜检查结果。对于一些患者，在排除先天性和遗传性毛发稀少症的所有其他可能病因后，应考虑散发性单纯性头皮毛发稀少症的诊断。
