石化研究机构颅内肿瘤的病例系列调查。

Case-series investigation of intracranial neoplasms at a petrochemical research facility.

作者信息

Delzell E, Beall C, Rodu B, Lees P S, Breysse P N, Cole P

机构信息

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, USA.

出版信息

Am J Ind Med. 1999 Oct;36(4):450-8. doi: 10.1002/(sici)1097-0274(199910)36:4<450::aid-ajim6>3.0.co;2-7.

DOI:10.1002/(sici)1097-0274(199910)36:4<450::aid-ajim6>3.0.co;2-7

PMID:10470010

Abstract

BACKGROUND

From 1970 through 1997, 17 intracranial neoplasms were identified among 6,800 employees of a petrochemical research facility. This investigation describes the case-series.

METHODS

The intracranial neoplasms were identified by self reports and record linkages, and were confirmed by medical records and a pathology review. Standardized incidence ratios (SIRs) compare observed and expected numbers of cases according to certain work characteristics.

RESULTS

Overall, there were 17 observed and 10.5 expected intracranial neoplasms, including 11/4.7 benign intracranial tumors and 6/5.9 brain cancers. All brain cancers occurred among male research scientists or technicians. Four had worked at some time on the same floor of one building (SIR=12.6, 95% CI=3.4-32.1), and several had worked on a research project with at least one other brain cancer case. The benign intracranial neoplasm cases did not have common building assignments or work activities.

CONCLUSIONS

The occurrence pattern of brain cancers, but not that of benign tumors, suggests a possible occupational etiology.

摘要

背景

1970年至1997年期间，在一家石化研究机构的6800名员工中发现了17例颅内肿瘤。本调查描述了该病例系列。

方法

通过自我报告和记录链接识别颅内肿瘤，并通过病历和病理检查进行确认。标准化发病比（SIR）根据某些工作特征比较观察到的和预期的病例数。

结果

总体而言，观察到17例颅内肿瘤，预期为10.5例，包括11例/4.7例良性颅内肿瘤和6例/5.9例脑癌。所有脑癌均发生在男性研究科学家或技术人员中。有4人曾在同一栋楼的同一楼层工作过一段时间（SIR = 12.6，95% CI = 3.4 - 32.1），还有几人与至少一名其他脑癌病例共同参与过一个研究项目。良性颅内肿瘤病例没有共同的建筑物分配或工作活动。