Camacho L H, Wilairatana P, Weiss G, Mercader M A, Brittenham G M, Looareesuwan S, Gordeuk V R
Department of Medicine, George Washington University Medical Center, Washington DC, USA.
Trop Med Int Health. 1999 Jul;4(7):471-5. doi: 10.1046/j.1365-3156.1999.00426.x.
To examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (r = 0.65, P = 0.006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia.
为研究急性恶性疟原虫疟疾后免疫反应与血液学恢复之间的可能关系，我们对70名成年泰国患者在开始有效治疗后的4周内跟踪监测了外周血嗜酸性粒细胞计数和血红蛋白浓度。嗜酸性粒细胞由Th-2细胞因子以及其他刺激因素诱导产生。就诊时仅有8名（11%）受试者的嗜酸性粒细胞计数升高，但到第7天时65名（93%）受试者的嗜酸性粒细胞计数增加。然后嗜酸性粒细胞计数在第14天时显著下降，随后再次升高直至第28天。在16名无粪便寄生虫的受试者（r = 0.65，P = 0.006）以及54名有粪便寄生虫的患者（r = 0.32；P = 0.0019）中，均发现第7天的嗜酸性粒细胞计数峰值与第28天的血红蛋白浓度之间存在显著正相关。这些结果表明，完成抗疟治疗后不久出现强烈的嗜酸性粒细胞反应预示着疟疾相关贫血能良好恢复。
