依布硒啉类似物2-(4-氯苯基)-1,2-苯并异硒唑-3(2H)-酮的抗真菌活性

Antifungal activity of 2-(4-chlorophenyl)-1,2-benzisoselenazol-3(2H)-one, the analog of Ebselen.

作者信息

Bień M, Błaszczyk B, Kalinowska K, Młochowski J, Inglot A D

机构信息

Department of Microbiology, University of Wrocław, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1999;47(3):185-93.

PMID:10470446

Abstract

The antimicrobial activity of 8 selenoorganic compounds (3-benzisoselenazoles, 1-benzisoselenazolone oxide and 4-disaryl diselenides) was investigated. It was found that selenoorganic compounds from benzisoselenazolone group suppress growth of some fungi and bacteria. The growth of Saccharomyces cerevisiae sigma 127-8b and Candida albicans 258 strains was strongly inhibited by the 2-(4-chlorophenyl)-1,2-benzisoselenazol-3(2H)-one. Also Ebselen and 2-acetyl-1,2-benzisoselenazol-3(2H)-one caused strong inhibition of Saccharomyces cerevisiae sigma 127-8b growth but a lower effect was observed in assays with Candida sp. strains. Benzisoselenazolones were also found to have antibacterial activities. They significantly reduced the growth of Gram-negative Escherichia coli K-12 ROW and Gram-positive Staphylococcus aureus 209P (Oxford) bacteria strains.

摘要

研究了8种有机硒化合物（3-苯并异硒唑、1-苯并异硒唑酮氧化物和4-二芳基二硒醚）的抗菌活性。发现苯并异硒唑酮类有机硒化合物能抑制某些真菌和细菌的生长。2-(4-氯苯基)-1,2-苯并异硒唑-3(2H)-酮强烈抑制酿酒酵母sigma 127-8b和白色念珠菌258菌株的生长。依布硒仑和2-乙酰基-1,2-苯并异硒唑-3(2H)-酮也对酿酒酵母sigma 127-8b的生长有强烈抑制作用，但在念珠菌属菌株的检测中观察到的效果较低。还发现苯并异硒唑酮具有抗菌活性。它们显著降低了革兰氏阴性大肠杆菌K-12 ROW和革兰氏阳性金黄色葡萄球菌209P（牛津）菌株的生长。