Peltola H
Department of Infectious Diseases, Helsinki University Central Hospital, Finland.
Infect Dis Clin North Am. 1999 Sep;13(3):685-710, viii. doi: 10.1016/s0891-5520(05)70101-x.
A comprehensive review of all major agents causing bacterial meningitis--meningococcus of the groups A, B, C, W135, and Y, pneumococcus, and Haemophilus influenzae type B (Hib)--is done in terms of preventing them by chemoprophylaxis or vaccination. Some evidence suggests that the group B meningococcal disease may also be very likely preventable by a vaccine that is already available. Excellent Hib conjugates use a technique that is expected to revolutionize immunoprophylaxis against most meningococcal and pneumococcal diseases in the near future. Unfortunately, the high cost of conjugate vaccines restricts their use in many poor countries.
对所有引起细菌性脑膜炎的主要病原体——A、B、C、W135和Y群脑膜炎球菌、肺炎球菌以及B型流感嗜血杆菌（Hib）进行了全面综述，内容涉及通过化学预防或疫苗接种来预防这些病原体。一些证据表明，B群脑膜炎球菌病也很可能可以通过现有的一种疫苗来预防。出色的Hib结合疫苗采用的技术有望在不久的将来彻底改变针对大多数脑膜炎球菌和肺炎球菌疾病的免疫预防。不幸的是，结合疫苗的高成本限制了它们在许多贫穷国家的使用。
