Taylor G A, Barnewolt C E, Claudon M, Dunning P S
Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
AJR Am J Roentgenol. 1999 Sep;173(3):757-60. doi: 10.2214/ajr.173.3.10470918.
Our purpose was to test the feasibility and optimization of contrast-enhanced gray-scale harmonic sonography for the evaluation of focal renal perfusion defects in an animal model.
We performed arteriography and contrast-enhanced harmonic sonography on six anesthetized piglets after embolization of each kidney with an autologous clot through the main renal artery. Harmonic images were obtained with continuous (30 Hz) and ECG-triggered acquisition. The two harmonic sonography strategies were compared with respect to the number and conspicuity of devascularized areas, and correlation was made with arteriographic findings.
Contrast-enhanced harmonic sonography showed focal areas of absent or diminished vascularity that corresponded closely with perfusion defects seen on angiography. Enhancement ratios to perfused cortex were significantly higher than to devascularized cortex in both continuous (mean +/- SD, 469 +/- 5% versus 102 +/- 8%, p < .0005 by t test) and triggered (673 +/- 7% versus 198 +/- 7%, p < .0001) modes. Triggered acquisition increased the conspicuity of perfusion defects over that obtained with continuous imaging (p < .002 by t test).
Contrast-enhanced harmonic sonography is an effective method of depicting focal renal perfusion defects. Triggered acquisition further improves lesion conspicuity.
我们的目的是在动物模型中测试对比增强灰阶谐波超声检查评估局灶性肾灌注缺损的可行性及优化方法。
我们对6只麻醉的仔猪进行了动脉造影和对比增强谐波超声检查，通过肾动脉主干用自体血凝块栓塞每只肾脏。采用连续（30Hz）和心电图触发采集获取谐波图像。比较两种谐波超声检查策略在无血管区数量和清晰度方面的差异，并与动脉造影结果进行相关性分析。
对比增强谐波超声检查显示的无血管或血管减少的局灶区域与血管造影所见的灌注缺损密切对应。在连续（平均±标准差，469±5%对102±8%，t检验p<.0005）和触发（673±7%对198±7%，p<.0001）模式下，灌注皮质的增强比均显著高于无血管皮质。与连续成像相比，触发采集提高了灌注缺损的清晰度（t检验p<.002）。
对比增强谐波超声检查是描绘局灶性肾灌注缺损的有效方法。触发采集进一步提高了病变的清晰度。
