Laposata M
Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston 02114, USA.
Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):313-5. doi: 10.1016/s0952-3278(99)80005-2.
Increasing evidence indicates that fatty acid ethyl esters (FAEE) play a role in ethanol-induced organ damage and may serve as long-term markers of ethanol intake. This report summarizes the current knowledge on the toxicity of FAEE, the enzymes associated with FAEE synthesis, FAEE as fatty acid supplements, the in vivo degradation of orally ingested FAEE and FAEE as markers of ethanol intake. A list of major unanswered questions in each of these categories is also included.
越来越多的证据表明，脂肪酸乙酯（FAEE）在乙醇诱导的器官损伤中起作用，并且可能作为乙醇摄入量的长期标志物。本报告总结了目前关于FAEE毒性、与FAEE合成相关的酶、作为脂肪酸补充剂的FAEE、口服摄入的FAEE在体内的降解以及作为乙醇摄入量标志物的FAEE的知识。每个类别中主要未解决问题的列表也包括在内。
