Callesen T, Hjort D, Mogensen T, Schouenborg L, Nielsen D, Reventlid H, Kehlet H
Department of Anaesthesiology, H:S Hvidovre University Hospital, Denmark.
Br J Anaesth. 1999 Apr;82(4):586-90. doi: 10.1093/bja/82.4.586.
We have studied the effect of ropivacaine for combined port site and mesosalpinx infiltration, and peritoneal instillation on pain, nausea and vomiting after laparoscopic sterilization, in a double-blind, placebo-controlled study in 80 patients. The total dose of ropivacaine was 285 mg. All patients received intra- and postoperative NSAID in fixed doses. Abdominal and shoulder pain, nausea and vomiting were recorded during the first 8 h after operation and in a diary for 3 days. In the ropivacaine group, abdominal pain scores were lower during the first 4 h (P < 0.00001), additional use of morphine was less (P < 0.001) and fewer patients had nausea or vomiting during the first 72 h (five vs 14; P < 0.05). There were no signs of local anaesthetic toxicity.
在一项针对80例患者的双盲、安慰剂对照研究中,我们研究了罗哌卡因用于联合穿刺孔和输卵管系膜浸润以及腹腔内滴注对腹腔镜绝育术后疼痛、恶心和呕吐的影响。罗哌卡因的总剂量为285mg。所有患者均接受固定剂量的术中和术后非甾体抗炎药。术后前8小时以及术后3天的日记中记录腹部和肩部疼痛、恶心和呕吐情况。在罗哌卡因组,前4小时腹部疼痛评分较低(P<0.00001),吗啡的额外使用较少(P<0.001),且在前72小时内恶心或呕吐的患者较少(5例对14例;P<0.05)。没有局部麻醉药毒性的迹象。