Koeck J L, Modica C, Tual F, Czarnecki E, Fabre R, Merle C, Montfort F, Jouvenin N, Cavallo J D
Laboratoire de Biologie Clinique, Centre Hospitalier des Armées Bouffard.
Med Trop (Mars). 1999;59(1):35-8.
An unprecedented pocket of intestinal schistosomiasis was discovered in the Republic of Djibouti in 1997. The first cases were diagnosed in French and Djiboutian tourists who presented initial symptoms of bilharzian infection after bathing in the fresh-water basin under Hassan Gari Bira Falls, near Randa. Seventeen cases were subsequently confirmed by detection of anti-schistosome antibodies using indirect hemagglutination (IH) and indirect immunofluorescence (IIF) and/or detection of Schistosoma mansoni eggs in the stool. Further testing was performed in 35 village inhabitants, mostly children, who had been exposed by bathing in the basin. The IH reaction was positive in 28 patients (80 p. 100) including 17 (49 p. 100) with levels greater than 1/64. In 92 p. 100 of cases, IH findings were confirmed by IIF which indicated that association with hypereosinophilia was common. Schistosoma mansoni eggs were found in stools from 7 patients (19 p. 100) who generally displayed mild hypereosinophilia. Information concerning the zone of risk was distributed and control measures were undertaken as widely as possible in Djibouti and abroad.
1997年,在吉布提共和国发现了一个前所未有的肠道血吸虫病疫源地。首批病例是在法国和吉布提游客中诊断出来的,他们在兰达附近哈桑·加里·比拉瀑布下的淡水水潭中沐浴后,出现了血吸虫感染的初期症状。随后通过间接血凝试验(IH)和间接免疫荧光试验(IIF)检测抗血吸虫抗体和/或在粪便中检测曼氏血吸虫卵,确诊了17例病例。对35名曾在水潭中沐浴而接触过疫源地的村民(大多数是儿童)进行了进一步检测。28例患者(80%)的IH反应呈阳性,其中17例(49%)滴度大于1/64。在92%的病例中,IIF证实了IH的结果,表明伴有嗜酸性粒细胞增多很常见。在7名患者(19%)的粪便中发现了曼氏血吸虫卵,这些患者一般表现为轻度嗜酸性粒细胞增多。已发布了有关危险区域的信息,并在吉布提国内外尽可能广泛地采取了控制措施。