基底细胞痣综合征患者转移性基底细胞癌的神经内分泌分化

Neuroendocrine differentiation of a metastatic basal cell carcinoma in a patient with basal cell nevus syndrome.

作者信息

Tawfik O, Casparian J M, Garrigues N, Smith S, Kestenbaum T, Chamberlin F, Khan Q S

机构信息

Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA.

出版信息

J Cutan Pathol. 1999 Jul;26(6):306-10. doi: 10.1111/j.1600-0560.1999.tb01849.x.

DOI:10.1111/j.1600-0560.1999.tb01849.x

PMID:10472760

Abstract

A 48 year-old white male with basal cell nevus syndrome presented with a metastatic basal cell carcinoma with neuroendocrine features. The tumor manifested aggressive behavior, having deep local invasion and metastases to para-aortic lymph nodes and bone. Neuroendocrine differentiation has rarely been associated with basal cell carcinoma. The histologic, immunohistochemical, and electron microscopic studies of this rare tumor are described.

摘要

一名患有基底细胞痣综合征的48岁白人男性出现了具有神经内分泌特征的转移性基底细胞癌。该肿瘤表现出侵袭性，具有深部局部浸润，并转移至主动脉旁淋巴结和骨骼。神经内分泌分化很少与基底细胞癌相关。本文描述了对这种罕见肿瘤的组织学、免疫组织化学和电子显微镜研究。