Brodin P, Gottikh M, Auclair C, Mouscadet J F
CNRS-UMR 1772, Institut Gustave Roussy, Villejuif, France.
Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1717-8. doi: 10.1080/07328319908044831.
HIV-1 DNA integration is carried out by integrase, a viral protein which binds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations of mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which were designed to form an alternate strand triple helix with the U5 LTR end containing two adjacent purine tracts on opposite strands 5'-GGAAAATCTCT-3'/3'-CCTTTTAGAGA-5'.
