Pasichnichenko O M, Skok V I
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Fiziol Zh (1994). 1999;45(4):55-60.
Effects of tachykinin NK-3 receptors antagonist SR 142801 on the synaptic transmission in the rat's caudal mesenteric ganglion were investigated using extracellular recording of compound action potentials (CAPs) from the ganglion nerves. It is shown that antagonist of NK-3 receptors SR 142801 (2.5.10(-7) mol/l) decreased the amplitude and square of CAPs obtained by stimulating of intermesenteric nerve (IMN) and leading off from the colonic nerve, after high-frequency stimulation of IMN. It is suggests that tachykinin NK-3 receptors take part in SP-ergic synaptic transmission through the rat's caudal mesenteric ganglion.
使用细胞外记录法记录大鼠尾肠系膜神经节神经复合动作电位（CAPs），研究速激肽NK-3受体拮抗剂SR 142801对大鼠尾肠系膜神经节突触传递的影响。结果显示，在高频刺激肠系膜间神经（IMN）后，NK-3受体拮抗剂SR 142801（2.5×10⁻⁷mol/l）可降低通过刺激IMN并从结肠神经引出的CAPs的幅度和平方。这表明速激肽NK-3受体参与通过大鼠尾肠系膜神经节的P物质能突触传递。
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