Moriyama Y
Department of Medicine, Tsubame Rosai Hospital.
Rinsho Byori. 1999 May;Suppl 110:79-84.
Relapse due to either residual host disease or reinfused tumor cells remains the principal cause of treatment failure after autologous stem cell transplantation. It is very attractive to remove contaminated tumor cells from autologous grafts prior to transplant and many purging techniques including hyperthermia we developed, have been reported on this subject. However, there are only limited data suggesting that purging autografts have any favorable effect on relapses or disease-free survival. Drug-treated purging and CD34 positive cell selections that remove substantial numbers of T cells or destroy stem cells may have adverse effects such as delayed hematopoietic or T cell recovery. Therefore, there is a critical need for large, well-designed trials to re-evaluate ex vivo and in vivo purging effects on relapses and disease-free survival after autologous stem cell transplantation.
由于残留的宿主疾病或重新注入的肿瘤细胞导致的复发仍然是自体干细胞移植后治疗失败的主要原因。在移植前从自体移植物中去除受污染的肿瘤细胞极具吸引力，并且已经报道了许多包括我们开发的热疗在内的净化技术。然而，仅有有限的数据表明净化自体移植物对复发或无病生存期有任何有利影响。药物处理净化和去除大量T细胞或破坏干细胞的CD34阳性细胞分选可能会产生诸如造血或T细胞恢复延迟等不良反应。因此，迫切需要进行大规模、精心设计的试验，以重新评估体外和体内净化对自体干细胞移植后复发和无病生存期的影响。
