Sing A, Leitritz L, Roggenkamp A, Kolb H J, Szabados A, Fingerle V, Autenrieth I B, Heesemann J
Max-von-Pettenkofer-Institut für Hygiene and Medizinische Mikrobiologie, and Medizinische Klinik III, Ludwig-Maximilians-Universität, Munich, Germany.
Clin Infect Dis. 1999 Aug;29(2):429-33. doi: 10.1086/520228.
Toxoplasma gondii may cause disseminated disease in bone marrow transplant (BMT) recipients. Pulmonary toxoplasmosis in BMT patients is rarely described. Mortality rates of >90% have been previously reported. Since pulmonary toxoplasmosis is extremely difficult to diagnose, it is very often detected only at autopsy. Two cases of pulmonary toxoplasmosis in BMT recipients that were diagnosed by visualization of T. gondii tachyzoites in bronchoalveolar lavage fluid and by a new semi-nested PCR method amplifying 18S rRNA from bronchoalveolar lavage fluid are presented, and the literature on pulmonary toxoplasmosis in BMT patients is reviewed.
刚地弓形虫可在骨髓移植（BMT）受者中引起播散性疾病。BMT患者的肺弓形虫病鲜有报道。此前曾报告死亡率>90%。由于肺弓形虫病极难诊断，往往仅在尸检时才被发现。本文介绍了2例BMT受者肺弓形虫病病例，通过支气管肺泡灌洗（BAL）液中刚地弓形虫速殖子的可视化及一种从BAL液中扩增18S rRNA的新型半巢式PCR方法得以诊断，并对BMT患者肺弓形虫病的文献进行了综述。
