Tsai S J, Chiu H J, Wang Y C, Hong C J
Department of Psychiatry, Veterans General Hospital-Taipei, School of Medicine, National Yang-Ming University, Taiwan, ROC.
Neurosci Lett. 1999 Aug 20;271(2):135-7. doi: 10.1016/s0304-3940(99)00542-x.
The relative abundance of serotonin type 6 receptors (5-HT6) in some limbic regions and the high affinity of some antipsychotics to 5-HT6 receptors suggest that they might be involved in the pathogenesis of schizophrenic disorders. In a population-based association study, we tested the hypothesis that the allelic variant, C267T, of the human 5-HT6 gene confers susceptibility to schizophrenic disorders and associated aggressive behavior. We genotyped 5-HT6 receptors in 186 patients with schizophrenic disorders and 163 controls. The results demonstrated no significant difference in genotype or allele frequencies between patients with or without aggressive behaviors. However, genotype distribution was significantly different between schizophrenic patients and control subjects. This suggests that the 5-HT6 gene may play a role in the pathogenesis of schizophrenic disorders.
5-羟色胺6型受体（5-HT6）在某些边缘系统区域的相对丰度以及某些抗精神病药物对5-HT6受体的高亲和力表明，它们可能参与了精神分裂症的发病机制。在一项基于人群的关联研究中，我们检验了以下假设：人类5-HT6基因的等位基因变体C267T赋予了对精神分裂症及相关攻击行为的易感性。我们对186例精神分裂症患者和163名对照者的5-HT6受体进行了基因分型。结果显示，有或没有攻击行为的患者之间，基因型或等位基因频率没有显著差异。然而，精神分裂症患者与对照者之间的基因型分布存在显著差异。这表明5-HT6基因可能在精神分裂症的发病机制中起作用。
