• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cisplatin-resistant derivatives of murine L1210 leukemia cells are not susceptible to growth-inhibiting and apoptosis-inducing actions of transforming growth factor-beta1.

作者信息

Stoika R S, Yakymovych I A, Chekhun V F

机构信息

Division of Regulatory Cell Systems, Institute of Biochemistry, National Academy of Sciences of Ukraine, Lviv.

出版信息

Anticancer Drugs. 1999 Jun;10(5):457-63. doi: 10.1097/00001813-199906000-00005.

DOI:10.1097/00001813-199906000-00005
PMID:10477165
Abstract

Murine L1210 leukemia cells possessing an increased resistance to cisplatin were found to be refractory to transforming growth factor (TGF)-beta1-induced growth inhibition, while the parental L1210 cells were strongly inhibited by this cytokine. Growth inhibition was estimated on the basis of [3H]thymidine incorporation, cell counting and colony-forming assay. Cisplatin-resistant L1210 cells were also shown to be much more resistant than the parental cells to both cisplatin- and TGF-beta1-induced apoptosis. These results suggest the existence of cross-resistance to cisplatin and TGF-beta1 in the studied leukemia cells.

摘要

相似文献

1
Cisplatin-resistant derivatives of murine L1210 leukemia cells are not susceptible to growth-inhibiting and apoptosis-inducing actions of transforming growth factor-beta1.
Anticancer Drugs. 1999 Jun;10(5):457-63. doi: 10.1097/00001813-199906000-00005.
2
Potential role of transforming growth factor beta1 in drug resistance of tumor cells.转化生长因子β1在肿瘤细胞耐药中的潜在作用。
Acta Biochim Pol. 2003;50(2):497-508.
3
Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments.顺铂耐药的L1210细胞中凋亡过程的缺陷不能解释细胞对各种药物治疗的反应。
Biochem Biophys Res Commun. 1997 May 29;234(3):573-7. doi: 10.1006/bbrc.1997.6674.
4
P-glycoprotein depresses cisplatin sensitivity in L1210 cells by inhibiting cisplatin-induced caspase-3 activation.P-糖蛋白通过抑制顺铂诱导的 caspase-3 激活来降低 L1210 细胞对顺铂的敏感性。
Toxicol In Vitro. 2012 Apr;26(3):435-44. doi: 10.1016/j.tiv.2012.01.014. Epub 2012 Jan 17.
5
Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells.线粒体动力学在顺铂抗白血病 L1210 细胞中的作用。
Oncol Rep. 2017 Aug;38(2):985-992. doi: 10.3892/or.2017.5765. Epub 2017 Jun 28.
6
Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline.对顺铂耐药的L1210小鼠白血病细胞亚系中甲氨蝶呤耐药机制的研究。
Cancer Chemother Pharmacol. 1996;37(4):337-42. doi: 10.1007/s002800050394.
7
[Cisplatin resistance in a murine leukemia cell line associated with defect of apoptosis].[与凋亡缺陷相关的小鼠白血病细胞系中的顺铂耐药性]
Bull Cancer. 1996 May;83(5):371-8.
8
Cisplatin resistance in a murine leukemia cell line is associated with a defective apoptotic process.一种小鼠白血病细胞系中的顺铂耐药性与凋亡过程缺陷有关。
Exp Cell Res. 1995 May;218(1):201-12. doi: 10.1006/excr.1995.1148.
9
The formation and repair of cisplatin-DNA adducts in wild-type and cisplatin-resistant L1210 cells: comparison of immunocytochemical determination with detection in isolated DNA.野生型和顺铂耐药L1210细胞中顺铂-DNA加合物的形成与修复：免疫细胞化学测定与分离DNA检测的比较
Chem Biol Interact. 1998 Jan 30;108(3):209-25. doi: 10.1016/s0009-2797(97)00108-7.
10
Cytotoxicity, cellular uptake and DNA binding of the novel trinuclear platinun complex BBR 3464 in sensitive and cisplatin resistant murine leukemia cells.
Anticancer Res. 1998 Jul-Aug;18(4C):3113-7.

引用本文的文献

1
Cytochemical study of role of alpha-d-mannose- and beta-d-galactose-containing glycoproteins in apoptosis.含α-D-甘露糖和β-D-半乳糖的糖蛋白在细胞凋亡中作用的细胞化学研究
J Mol Histol. 2004 Nov;35(8-9):829-38. doi: 10.1007/s10735-004-1674-z.