Zidek Z
Institute of Pharmacology, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic.
Eur Cytokine Netw. 1999 Sep;10(3):319-28.
Adenosine and cAMP are potent modulators of immune-triggered cytokine production. Their effects overlap with regard to the inhibition of the pro-inflammatory cytokines TNF-alpha, IFN-gamma, IL-12, and the stimulation of production of the major anti-inflammatory cytokine IL-10. They may tentatively be considered to be upregulators of the production of Th2 cytokines (IL-10, IL-6), but downregulators of the production of Th1 cytokines (IL-2 and IFN-gamma). Cytokines produced in common by Th0, Th1 and Th2 cells are affected as well, although the low quantity and heterogeneity of the contemporary experimental data do not allow unambiguous conclusions to be drawn. Nevertheless, IL-3, IL-4, MIP-1alpha/beta and GM-CSF have usually been found to be inhibited, IL-5 stimulated, while IL-1 remains largely unaffected by adenosine or cAMP. These effects, and in particular the inhibition of TNF-alpha and stimulation of IL-10 expression, might be of therapeutic value in a variety of pathophysiological conditions.
腺苷和环磷酸腺苷（cAMP）是免疫触发的细胞因子产生的强效调节剂。它们在抑制促炎细胞因子肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、白细胞介素-12（IL-12）以及刺激主要抗炎细胞因子白细胞介素-10（IL-10）产生方面的作用存在重叠。它们可能初步被认为是Th2细胞因子（IL-10、IL-6）产生的上调因子，但却是Th1细胞因子（IL-2和IFN-γ）产生的下调因子。Th0、Th1和Th2细胞共同产生的细胞因子也会受到影响，尽管目前实验数据的数量较少且存在异质性，无法得出明确结论。然而，通常发现IL-3、IL-4、巨噬细胞炎症蛋白-1α/β（MIP-1α/β）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）受到抑制，IL-5受到刺激，而IL-1在很大程度上不受腺苷或cAMP的影响。这些作用，尤其是对TNF-α的抑制和IL-10表达的刺激，在多种病理生理状况下可能具有治疗价值。
