Ulibarri J A, Mozdziak P E, Schultz E, Cook C, Best T M
Department of Pathology, University of Wisconsin Medical School, Madison 53711, USA.
In Vitro Cell Dev Biol Anim. 1999 Apr;35(4):215-8. doi: 10.1007/s11626-999-0029-1.
Nitric oxide (NO) is an inter- and intracellular messenger involved in a variety of physiologic and pathophysiologic conditions. The effect of two NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP) and their effect on myoblast proliferation was examined. Both donors stimulated an increase in myoblast cell number over a range (1-10 microM) of donor concentrations. However, 50 microM SNAP inhibited myoblast proliferation. Cell numbers from cultures treated with degraded 10 microM SNAP were equivalent to the control. Therefore, it appears NO can stimulate as well as inhibit myoblast proliferation.
一氧化氮（NO）是一种参与多种生理和病理生理状况的细胞间和细胞内信使。研究了两种NO供体硝普钠（SNP）和S-亚硝基-N-乙酰青霉胺（SNAP）及其对成肌细胞增殖的影响。在供体浓度范围（1-10 microM）内，两种供体均刺激成肌细胞数量增加。然而，50 microM的SNAP抑制成肌细胞增殖。用降解的10 microM SNAP处理的培养物中的细胞数量与对照相当。因此，似乎NO既能刺激也能抑制成肌细胞增殖。
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