奥里萨宾V - VIII，来自墨西哥药旋花根（Ipomoea orizabensis）的四糖糖脂。

Orizabins V-VIII, tetrasaccharide glycolipids from the Mexican scammony root (Ipomoea orizabensis).

作者信息

Hernández-Carlos B, Bye R, Pereda-Miranda R

机构信息

Departamento de Farmacia, Facultad de Química, and Jardín Botánico, Instituto de Biología, Universidad Nacional Autónoma de México, Coyoacán 04510, D.F., México.

出版信息

J Nat Prod. 1999 Aug;62(8):1096-100. doi: 10.1021/np9900627.

DOI:10.1021/np9900627

PMID:10479311

Abstract

An extensive investigation of the so-called jalapin resinoid obtained from roots of the Mexican scammony, Ipomoea orizabensis, using high field NMR spectroscopy led to the characterization of six glycosides, including the known scammonins I (1) and II (2) and four new tetrasaccharides of jalapinolic acid, orizabins V-VIII (3-6). All the isolates (1-6) were found to be weakly cytotoxic toward human oral epidermoid carcinoma (KB).

摘要

利用高场核磁共振光谱对从墨西哥泻根（Ipomoea orizabensis）根部获得的所谓药喇叭树脂进行了广泛研究，鉴定出六种糖苷，包括已知的药喇叭皂苷I（1）和II（2）以及四种新的药喇叭油酸四糖，即奥里萨宾V - VIII（3 - 6）。发现所有分离物（1 - 6）对人口腔表皮样癌（KB）具有弱细胞毒性。