CCAA核苷酸重复序列在流感嗜血杆菌血红蛋白及血红蛋白-结合珠蛋白结合蛋白基因调控中的作用
Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae.
作者信息
Ren Z, Jin H, Whitby P W, Morton D J, Stull T L
机构信息
Departments of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
出版信息
J Bacteriol. 1999 Sep;181(18):5865-70. doi: 10.1128/JB.181.18.5865-5870.1999.
Abstract
Haemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as heme sources. The H. influenzae hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZ translational gene fusion, we demonstrate phase-variable expression of lacZ associated with alteration in the length of the CCAA repeat region.
摘要
流感嗜血杆菌利用血红蛋白和血红蛋白-触珠蛋白作为血红素来源。流感嗜血杆菌的血红蛋白和血红蛋白-触珠蛋白结合蛋白基因hgpA、hgpB和hgpC含有四聚体CCAA重复序列。利用hgpA-lacZ翻译基因融合，我们证明了与CCAA重复区域长度改变相关的lacZ的相变表达。
相似文献
1
Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae.
J Bacteriol. 1999 Sep;181(18):5865-70. doi: 10.1128/JB.181.18.5865-5870.1999.
2
Distribution of a family of Haemophilus influenzae genes containing CCAA nucleotide repeating units.
FEMS Microbiol Lett. 1999 May 15;174(2):303-9. doi: 10.1111/j.1574-6968.1999.tb13583.x.
3
hgpB, a gene encoding a second Haemophilus influenzae hemoglobin- and hemoglobin-haptoglobin-binding protein.
Infect Immun. 1998 Oct;66(10):4733-41. doi: 10.1128/IAI.66.10.4733-4741.1998.
4
Characterization of hgpA, a gene encoding a haemoglobin/haemoglobin-haptoglobin-binding protein of Haemophilus influenzae.
Microbiology (Reading). 1999 Apr;145 ( Pt 4):905-914. doi: 10.1099/13500872-145-4-905.
5
Detection of phase variation in expression of proteins involved in hemoglobin and hemoglobin-haptoglobin binding by nontypeable Haemophilus influenzae.
Infect Immun. 2000 Jul;68(7):4092-101. doi: 10.1128/IAI.68.7.4092-4101.2000.
6
Effect of multiple mutations in the hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b.
Infect Immun. 1999 Jun;67(6):2729-39. doi: 10.1128/IAI.67.6.2729-2739.1999.
7
Identification of an outer membrane protein involved in utilization of hemoglobin-haptoglobin complexes by nontypeable Haemophilus influenzae.
Infect Immun. 1996 Sep;64(9):3703-12. doi: 10.1128/iai.64.9.3703-3712.1996.
8
Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection.
Infect Immun. 2006 Nov;74(11):6213-25. doi: 10.1128/IAI.00744-06. Epub 2006 Sep 11.
9
Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae.
Infect Immun. 1996 Aug;64(8):3134-41. doi: 10.1128/iai.64.8.3134-3141.1996.
10
Examination of phase-variable haemoglobin-haptoglobin binding proteins in non-typeable Haemophilus influenzae reveals a diverse distribution of multiple variants.
FEMS Microbiol Lett. 2022 Aug 1;369(1). doi: 10.1093/femsle/fnac064.
引用本文的文献
1
Exploiting haem-iron dependence of nontypeable : an avenue for future therapeutic development.
Front Cell Infect Microbiol. 2025 May 15;15:1548048. doi: 10.3389/fcimb.2025.1548048. eCollection 2025.
2
Examination of phase-variable haemoglobin-haptoglobin binding proteins in non-typeable Haemophilus influenzae reveals a diverse distribution of multiple variants.
FEMS Microbiol Lett. 2022 Aug 1;369(1). doi: 10.1093/femsle/fnac064.
3
No Change, No Life? What We Know about Phase Variation in .
Microorganisms. 2021 Jan 25;9(2):244. doi: 10.3390/microorganisms9020244.
4
Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct Specificity Genes That Can Switch System Specificity by Recombination.
mSystems. 2020 Jul 28;5(4):e00497-20. doi: 10.1128/mSystems.00497-20.
5
DNA sequence repeats identify numerous Type I restriction-modification systems that are potential epigenetic regulators controlling phase-variable regulons; phasevarions.
FASEB J. 2020 Jan;34(1):1038-1051. doi: 10.1096/fj.201901536RR. Epub 2019 Nov 28.
6
Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.
Nucleic Acids Res. 2018 Nov 30;46(21):11466-11476. doi: 10.1093/nar/gky913.
7
A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions.
Nucleic Acids Res. 2018 Apr 20;46(7):3532-3542. doi: 10.1093/nar/gky192.
8
Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.
Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13.
9
The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits.
Microb Pathog. 2016 Mar;92:60-67. doi: 10.1016/j.micpath.2015.12.006. Epub 2015 Dec 21.
10
Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.
J Infect Dis. 2015 Aug 15;212(4):645-53. doi: 10.1093/infdis/jiv103. Epub 2015 Feb 23.
本文引用的文献
1
Effect of multiple mutations in the hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b.
Infect Immun. 1999 Jun;67(6):2729-39. doi: 10.1128/IAI.67.6.2729-2739.1999.
2
Characterization of hgpA, a gene encoding a haemoglobin/haemoglobin-haptoglobin-binding protein of Haemophilus influenzae.
Microbiology (Reading). 1999 Apr;145 ( Pt 4):905-914. doi: 10.1099/13500872-145-4-905.
3
hgpB, a gene encoding a second Haemophilus influenzae hemoglobin- and hemoglobin-haptoglobin-binding protein.
Infect Immun. 1998 Oct;66(10):4733-41. doi: 10.1128/IAI.66.10.4733-4741.1998.
4
Short-sequence DNA repeats in prokaryotic genomes.
Microbiol Mol Biol Rev. 1998 Jun;62(2):275-93. doi: 10.1128/MMBR.62.2.275-293.1998.
5
Phase variation of hemoglobin utilization in Neisseria gonorrhoeae.
Infect Immun. 1998 Mar;66(3):987-93. doi: 10.1128/IAI.66.3.987-993.1998.
6
Tandem repeats of the tetramer 5'-CAAT-3' present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae.
Mol Microbiol. 1996 Apr;20(1):165-74. doi: 10.1111/j.1365-2958.1996.tb02498.x.
7
Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae.
Infect Immun. 1996 Aug;64(8):3134-41. doi: 10.1128/iai.64.8.3134-3141.1996.
8
Binding of human hemoglobin by Haemophilus influenzae.
FEMS Microbiol Lett. 1994 May 15;118(3):243-8. doi: 10.1111/j.1574-6968.1994.tb06835.x.
9
Adaptive evolution of highly mutable loci in pathogenic bacteria.
Curr Biol. 1994 Jan 1;4(1):24-33. doi: 10.1016/s0960-9822(00)00005-1.
10
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Science. 1995 Jul 28;269(5223):496-512. doi: 10.1126/science.7542800.
Zotero 插件