Inappropriate antidiuretic hormone secretion after high-dose thiotepa.

作者信息

Sica S, Cicconi S, Sorà F, Chiusolo P, Piccirillo N, Laurenti L, La Barbera E O, Giordano G, Leone G

机构信息

Divisione Ematologia, Istituto di Semeiotica Medica, Università Cattolica Sacro Cuore, Rome, Italy.

出版信息

Bone Marrow Transplant. 1999 Sep;24(5):571-2. doi: 10.1038/sj.bmt.1701922.

High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.