Mark H F, Sotomayor E, Mega A
Rhode Island Hospital, Brown University School of Medicine, Providence 02806, USA.
Exp Mol Pathol. 1999 Aug;66(3):238-42. doi: 10.1006/exmp.1999.2267.
While t(1;19) and t(8;14) have been reported singly in pre-B-ALL and Burkitt's lymphoma, respectively, the occurrence of both translocations simultaneously in the same patient is rare. Indeed, a review of the English literature from 1966 to 1999 revealed no case reports with these findings. We report here an 88-year-old patient who was clinically diagnosed to have chronic lymphocytic leukemia and who carried both translocations in her peripheral blood cells. The patient refused to give consent for a bone marrow sample, the preferred tissue for study. The patient's clinical findings are discussed, although the relationship between the clinical information and cytogenetic findings, if any, is not known. Study of additional cases identical to ours will be helpful in determining the correlation, if any, between the patient's phenotype and the occurrence of the two translocations.
虽然t(1;19)和t(8;14)分别在早前B淋巴细胞白血病和伯基特淋巴瘤中被单独报道过，但同一患者同时出现这两种易位的情况却很罕见。事实上，回顾1966年至1999年的英文文献，未发现有这些发现的病例报告。我们在此报告一名88岁的患者，临床诊断为慢性淋巴细胞白血病，其外周血细胞中携带这两种易位。患者拒绝同意获取骨髓样本，而骨髓样本是研究的首选组织。本文讨论了该患者的临床发现，尽管临床信息与细胞遗传学发现之间的关系（如果有的话）尚不清楚。研究与我们相同的其他病例将有助于确定患者表型与这两种易位发生之间是否存在关联（如果有的话）。
