N-丙酰基-D-甘露糖胺对大鼠肝脏二肽基肽酶IV酸性N-聚糖的体内调节作用
In vivo modulation of the acidic N-glycans from rat liver dipeptidyl peptidase IV by N-propanoyl-D-mannosamine.
作者信息
Stehling P, Grams S, Nuck R, Grunow D, Reutter W, Gohlke M
机构信息
Institut für Molekularbiologie and Biochemie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Arnimallee 22, Berlin-Dahlem, D-14195, Germany.
出版信息
Biochem Biophys Res Commun. 1999 Sep 16;263(1):76-80. doi: 10.1006/bbrc.1999.1326.
Derivatives of N-acyl-D-mannosamine differing in the N-acyl-side chain can be metabolically converted into neuraminic acids with corresponding N-acyl side chains. In the present study we show the in vivo modulation of sialic acids in membrane-bound dipeptidyl peptidase IV (CD 26) from rat liver after administration of N-propanoyl-D-mannosamine. Treatment of rats with this unphysiological precursor resulted in an incorporation of N-propanoylneuraminic acid into N-linked glycans of dipeptidyl peptidase IV.
N-酰基-D-甘露糖胺的衍生物在N-酰基侧链上存在差异，它们可以通过代谢转化为具有相应N-酰基侧链的神经氨酸。在本研究中，我们展示了在给予N-丙酰-D-甘露糖胺后，大鼠肝脏中膜结合二肽基肽酶IV（CD 26）中唾液酸的体内调节情况。用这种非生理性前体处理大鼠导致N-丙酰神经氨酸掺入二肽基肽酶IV的N-连接聚糖中。
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