Knake S, Hamer H M, Schomburg U, Oertel W H, Rosenow F
Philipps-University, Neurologische Klinik, Marburg, Germany.
Seizure. 1999 Aug;8(5):314-7. doi: 10.1053/seiz.1999.0303.
Several medications such as baclofen, amitriptyline and even antiepileptic drugs such as carbamazepine or vigabatrin are known to induce absence status epilepticus in patients with generalized epilepsies. Tiagabine (TGB) is effective in patients with focal epilepsies. However, TGB has also been reported to induce non-convulsive status epilepticus in several patients with focal epilepsies and in one patient with juvenile myoclonic epilepsy. In animal models of generalized epilepsy, TGB induces absence status with 3-5 Hz spike-wave complexes. We describe a 32-year-old patient with absence epilepsy and primary generalized tonic-clonic seizures since 11 years of age, who developed her first absence status epilepticus while treated with 45 mg of TGB daily. Administration of lorazepam and immediate reduction in TGB dosage was followed by complete clinical and electroencephalographic remission. This case demonstrates that TGB can induce typical absence status epilepticus in a patient with primary generalized epilepsy.
已知几种药物，如巴氯芬、阿米替林，甚至卡马西平或氨己烯酸等抗癫痫药物，可在全身性癫痫患者中诱发失神持续状态。噻加宾（TGB）对局灶性癫痫患者有效。然而，也有报道称，TGB在几名局灶性癫痫患者和一名青少年肌阵挛癫痫患者中诱发了非惊厥性癫痫持续状态。在全身性癫痫的动物模型中，TGB可诱发伴有3-5Hz棘慢复合波的失神状态。我们描述了一名32岁的患者，自11岁起患有失神癫痫和原发性全身性强直阵挛发作，在每天服用45mg TGB治疗期间首次发生失神持续状态。给予劳拉西泮并立即减少TGB剂量后，临床和脑电图完全缓解。该病例表明，TGB可在原发性全身性癫痫患者中诱发典型的失神持续状态。
